Welcome to the world of do what you got to do when you got to do it! Sometimes it's a choice on cheap, sometimes on size, sometimes on strength or frame features. If you have a body or cab style in mind, do some research to find the dimensions and then find a frame that would fit pretty good or would be easy to change to fit. You'll see alot old older trucks with smaller cabs being fitted to small truck frames like S-10s and Rangers. Why? because they fit pretty well...
Sometimes a frame is chosen because of it's features like IFS for fendered vehicles...they don't look that good on open fendered rides but if you can hide the BS, they make good cruisers with up to date suspensions.
If you are only considering a frame because it's titled, you may want to check with the DMV in your area. It might be exciting to be pulled over in a Model A and only have a registration for a Chevrolet frame.
Cruise the build threads here and see what guys are doing. It will give you unlimited ideas of what "can" be done. Some people will tell you it's not that hard to build your own frame. Then you fit it as needed for whatever you're building. Back to the first sentence....there's talent here that will show you that just about anything can be done! You're building a hotrod or rat if you like...do it the way you want it, but be safe! The guys here will tell you when you're screwing up with safety.