What Klink said X2. If you're planning to run fenders, the S10 steering box and frame horns are way too far out front to fit under the fenders. If you plan to go fenderless, the S10 IFS looks like butt.... The stock frame is a really good piece, with a little modifying would be the far better choice.
Here's a pic of a 34 I built with a Mustang II front end on the stock frame. I boxed the rest of the frame and added a K member in the middle to mount the tranny and stiffen it - rebuilt stock rear leafs. I actually did use an S10 rearend though, on 2" lowering blocks.