I really like this site and the folks on it...
BUT I'd like to recommend another site, if for nothing more than pointing you in a more brand-specific direction:
www.stovebolt.com
There are LOTS of good people over there, too-many are "resto only" guys, but a fair few are into modernizing, upgrading or just plain "modding" their trucks. If you spend some time reading their "Hi-Po Shop" forum, you may find a thread there covering your exact swap and any concerns pertaining to it. There, as with
many other places on the web, the "AD to S-10" swap has been about done to death.
If you do end up doing this, PLEASE share your results with a build thread here! It would be nice to see pics of a different type of body swap.
Thinking back on it, I seem to remember a member either here or over at killbillet.com who swapped a '39/'40 Chevy halfton onto a Toyota chassis powered by a Buick V-6... A few hours with the "search" button on several different forums will be time well spent researching.
Best of luck and keep us posted![P
Regards,
Shea