Well since you did ask, I think it will look like total ass without fenders, and especially on an S-10 chassis. All of that exposed IFS and steering that is unavoidable on the S-10 is big, clunky and just not attractive. Fine if you want to hide it underneath the entire body though, which is what I would advise you to do. You have the makings of a really neat little cruiser pickup there and it would be a shame to see it cut apart.
I think in the long run you will be much happier with something that is a little more classic, such as the trucks pictured earlier in the thread. It will also be much more practical and driveable, especially if you want to set the entire truck onto the S-10 chassis. (with the fenders!) I know it isn't "radical", but if that what you are looking for - especially if you want an open wheeled hot rod truck, you need to find something earlier and smaller. I know it is what you have, but if you build it right you may be able to sell it and get something more along the lines of what you are looking for. Or sell it now and start over. It is your truck, so by all means build it how you want. You asked for opinions and that is mine. Take it for what it is worth...