The S-10 frames are one of the easiest to shorten. There is already a slip-joint in the middle where you can easily remove material. You simply cut the weld at the front of the joint, separate the frame and remove material, slip it back together and weld it back up.
What is the wheelbase of your frame now, and what wheelbase are you wanting to get to?
There are 3 wheelbases of S-10, and 2 of Blazer:
S-10 Blazer 2 Door: 100.5" WB
S-10 Blazer 4 Door: 107" WB
S-10 Regular Cab Short Box: 108" WB
S-10 Regular Cab Long Box: 117" WB
S-10 Extended Cab Short Box: 123" WB
S-10 Crew Cab Short Box (2001-2004 only): 123" WB
The 117" WB is right for most regular cab shortbox vintage trucks, though some (like 55-56 dodges) did have a 108" WB. If you're wanting something super short hopefully the list above helps you. If you have a super long bed it sounds like you make have the extended cab short box at the moment.