it depends on what kind of car you are building. say if you are building a steel t roadster you can build a floor out of 16 gauge and roll some beads, with one or two sub frame rails where the body mounts are, i have seen and worked on some that dont even have sub frames in them and they are fine, i just like the extra reassurance. truck cabs are about the same. but on a sedan, coupe or later model full size a floor skeleton is a must in my book if you are cutting it all out for a channel or a custom floor. if you are just replacing floor pans just leave the original sub braces in and you will be fine
hope that helps