I kinda agree with OI about turning the carbs 90 degrees, same goes for the EFI top, turning the 4bbl 90 would also even up the distribution to the ports. I expect you would cut off the throttle body mount and weld in a plate for appearance sake at least...
Longer runners generally do improve low/mid range torque.
Probably the biggest issue with carbureting a dry manifold like this is the plenum volume, smaller is generally better for throttle response and avoiding the dreaded bog when you stomp on it.
Here's a thought - if you are removing the throttle body boss, putting a removable cover on it would give you access to fit different size/shape deflectors or contoured "plugs" into the plenum to reduce volume and direct flow to the ports.....[S[S